Microfluidic Tandem Mechanical Sorting System for Enhanced Cancer Stem Cell Isolation and Ingredient Screening (Adv. Healthcare Mater. 20/2021)

Metamaterials: Snapping Mechanical Metamaterials under Tension (Adv. Mater. 39/2015).

By exploiting snap-through instabilities, D. Pasini and co-workers design a damage-tolerant mechanical metamaterial that snaps sequentially under tension, thereby accommodating a very large deformation up to 150%. On page 5931, they describe how the nonlinear mechanical response of the metamaterial can be robustly programmed by tuning the architecture of its unit cell.

A Microfluidic Device for Sorting Liver Cancer Stem Cell in a Continuous Biological Fluid

In order to make possible the selective sorting of hepatocellular carcinoma stem cells (CD133+ HCC SCs) in biofluids without to use an antigen-antibody reaction to attach antibody-immobilized nanobeads to the surfaces of HCC SCs. The unique dielectric properties of HCC SC has been tested and obtained by the applying AC electrical field with various frequency and strength between an planar micro...

Materials and Wireless Microfluidic Systems for Electronics Capable of Chemical Dissolution on Demand (Adv. Funct. Mater. 92015)

Microfluidic system for on-chip high-throughput whole-animal sorting and screening at subcellular resolution.

We report a suite of key microfluidic devices for complex high-throughput whole-animal genetic and drug screens. We demonstrate a high-speed microfluidic sorter that can isolate and immobilize Caenorhabditis elegans in a well defined geometry for screening phenotypic features at subcellular resolution in physiologically active animals. We show an integrated chip containing individually addressa...

Skeletal stem cell isolation: A review on the state-of-the-art microfluidic label-free sorting techniques.

Skeletal stem cells (SSC) are a sub-population of bone marrow stromal cells that reside in postnatal bone marrow with osteogenic, chondrogenic and adipogenic differentiation potential. SSCs reside only in the bone marrow and have organisational and regulatory functions in the bone marrow microenvironment and give rise to the haematopoiesis-supportive stroma. Their differentiation capacity is re...